Version 5.4
Homo sapiens Protein: ARHGEF25
Summary
InnateDB Protein IDBP-43090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF25
Protein Name Rho guanine nucleotide exchange factor (GEF) 25
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000286494
InnateDB Gene IDBG-409398 (ARHGEF25)
Protein Structure
UniProt Annotation
Function May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11- coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269PubMed:11861769}. Note=Highly colocalizes with actin regions.
Disease Associations
Tissue Specificity Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver. {ECO:0000269PubMed:11861769, ECO:0000269PubMed:12547822, ECO:0000269PubMed:15069594}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030016 myofibril
GO:0030017 sarcomere
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86VW2
PhosphoSite PhosphoSite-Q86VW2
TrEMBL A0A024RBA8
UniProt Splice Variant
Entrez Gene 115557
UniGene
RefSeq NP_891992
HUGO HGNC:30275
OMIM 610215
CCDS CCDS8947
HPRD 13573
IMGT
EMBL AB370196 AC025165 AF487514 BC012860 BC018536 BC047559 CH471054
GenPept AAH12860 AAH18536 AAH47559 AAO49463 BAF94999 EAW97037 EAW97040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca