Version 5.4
Homo sapiens Gene: ARHGEF25
Summary
InnateDB Gene IDBG-409398.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF25
Gene Name Rho guanine nucleotide exchange factor (GEF) 25
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000240771
Encoded Proteins
IDBP-43090
Rho guanine nucleotide exchange factor (GEF) 25
IDBP-44402
Rho guanine nucleotide exchange factor (GEF) 25
IDBP-807623
Rho guanine nucleotide exchange factor (GEF) 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57610180-57619379
Strand Forward strand
Band q13.3
Transcripts
ENST00000286494 ENSP00000286494
ENST00000333972 ENSP00000335560
ENST00000471370
ENST00000469072
ENST00000466399
ENST00000484357
ENST00000477314
ENST00000616622 ENSP00000484303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030016 myofibril
GO:0030017 sarcomere
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019467
View Gene Order
ENSBTAG00000018003
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt Q86VW2
TrEMBL A0A024RBA8
UniProt Splice Variant
Entrez Gene 115557
UniGene
RefSeq NM_001111270 NM_182947
HUGO HGNC:30275
OMIM 610215
CCDS CCDS44931 CCDS8947
HPRD
IMGT
EMBL AB370196 AC025165 AF487514 BC012860 BC018536 BC047559 CH471054
GenPept AAH12860 AAH18536 AAH47559 AAO49463 BAF94999 EAW97037 EAW97040
RNA Seq Atlas 115557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca