InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LPIN2

Summary

InnateDB Protein

IDBP-431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPIN2

Protein Name

lipin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261596

InnateDB Gene

IDBG-429 (LPIN2)

Protein Structure

UniProt Annotation

Function

Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Translocates to endoplasmic reticulum membrane with increasing levels of oleate. {ECO:0000250}.

Disease Associations

Majeed syndrome (MAJEEDS) [MIM:609628]: An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). {ECO:0000269PubMed:15994876}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. {ECO:0000269PubMed:15994876, ECO:0000269PubMed:17158099}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0008195	phosphatidate phosphatase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0016311	dephosphorylation
GO:0019432	triglyceride biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046474	glycerophospholipid biosynthetic process