InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LPIN2

Summary

InnateDB Gene

IDBG-429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LPIN2

Gene Name

lipin 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000101577

Encoded Proteins

IDBP-431

lipin 2

IDBP-725680

IDBP-726346

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:2916994-3013315

Strand

Reverse strand

Band

p11.31

Transcripts

ENST00000261596	ENSP00000261596
ENST00000584294	ENSP00000463026
ENST00000581568
ENST00000584915	ENSP00000463810

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0008195	phosphatidate phosphatase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0016311	dephosphorylation
GO:0019432	triglyceride biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046474	glycerophospholipid biosynthetic process