InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM24

Summary

InnateDB Protein

IDBP-43166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM24

Protein Name

tripartite motif containing 24

Synonyms

hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA;

Species

Homo sapiens

Ensembl Protein

ENSP00000340507

InnateDB Gene

IDBG-43164 (TRIM24)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21164480}. Cytoplasm {ECO:0000269PubMed:21164480}. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.

Disease Associations

Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving TRIM24/TIF1 is found in thyroid papillary carcinomas. Translocation t(7;10)(q32;q11) with RET. The translocation generates the TRIM24/RET (PTC6) oncogene.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	85 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0016922	ligand-dependent nuclear receptor binding
GO:0034056	estrogen response element binding
GO:0043565	sequence-specific DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0031647	regulation of protein stability
GO:0042981	regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046777	protein autophosphorylation
GO:0055074	calcium ion homeostasis
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:0071391	cellular response to estrogen stimulus
GO:1901796	regulation of signal transduction by p53 class mediator

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005719	nuclear euchromatin
GO:0005726	perichromatin fibrils
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001487 Bromodomain
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003649 B-box, C-terminal
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM

PF00643
PF00439
PF13639
PF14634
PF00628

PRINTS

PR00503

PIRSF

SMART

SM00336
SM00297
SM00184
SM00249
SM00502

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt