Version 5.4
Homo sapiens Gene: TRIM24
Summary
InnateDB Gene IDBG-43164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM24
Gene Name tripartite motif containing 24
Synonyms hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA
Species Homo sapiens
Ensembl Gene ENSG00000122779
Encoded Proteins
IDBP-43166
tripartite motif containing 24
IDBP-386690
tripartite motif containing 24
IDBP-810067
tripartite motif containing 24
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23438823
TRIM24 was identified in a systematic screen for positive regulators of innate immune responses.
Entrez Gene
Summary The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:138460334-138589993
Strand Forward strand
Band q33
Transcripts
ENST00000343526 ENSP00000340507
ENST00000415680 ENSP00000390829
ENST00000497516
ENST00000464210
ENST00000485318
ENST00000493595
ENST00000620194 ENSP00000484482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 85 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0016922 ligand-dependent nuclear receptor binding
GO:0034056 estrogen response element binding
GO:0043565 sequence-specific DNA binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
GO:0031647 regulation of protein stability
GO:0042981 regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0055074 calcium ion homeostasis
GO:0070562 regulation of vitamin D receptor signaling pathway
GO:0071391 cellular response to estrogen stimulus
GO:1901796 regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
GO:0005726 perichromatin fibrils
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029833
View Gene Order
ENSBTAG00000002431
Not yet available
Pathways
NETPATH
REACTOME
REACT_121141
Signaling by FGFR1 fusion mutants pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003852 NM_015905
HUGO
OMIM
CCDS CCDS47720 CCDS5847
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca