InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPY1R

Summary

InnateDB Protein

IDBP-43205.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPY1R

Protein Name

neuropeptide Y receptor Y1

Synonyms

NPY1-R; NPYR;

Species

Homo sapiens

Ensembl Protein

ENSP00000354652

InnateDB Gene

IDBG-43203 (NPY1R)

Protein Structure

UniProt Annotation

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001601	peptide YY receptor activity
GO:0001602	pancreatic polypeptide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity
GO:0005515	protein binding

Biological Process

GO:0003151	outflow tract morphogenesis
GO:0006006	glucose metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007626	locomotory behavior
GO:0007631	feeding behavior
GO:0008217	regulation of blood pressure
GO:0019233	sensory perception of pain
GO:0040014	regulation of multicellular organism growth

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000351 Neuropeptide Y1 receptor
IPR000611 Neuropeptide Y receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR023041 Glucose receptor Git3, N-terminal

PFAM

PF00001
PF10320
PF11710

PRINTS

PR00237
PR01013
PR01012

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25929