Version 5.4
Homo sapiens Gene: NPY1R
Summary
InnateDB Gene IDBG-43203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPY1R
Gene Name neuropeptide Y receptor Y1
Synonyms NPY1-R; NPYR
Species Homo sapiens
Ensembl Gene ENSG00000164128
Encoded Proteins
IDBP-43205
neuropeptide Y receptor Y1
IDBP-481837
neuropeptide Y receptor Y1
IDBP-477882
neuropeptide Y receptor Y1
IDBP-483296
neuropeptide Y receptor Y1
IDBP-482752
neuropeptide Y receptor Y1
IDBP-480798
neuropeptide Y receptor Y1
IDBP-483914
neuropeptide Y receptor Y1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle (Herzog et al., 1992 [PubMed 1321422]).[supplied by OMIM, Mar 2008]
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:163323961-163344832
Strand Reverse strand
Band q32.2
Transcripts
ENST00000296533 ENSP00000354652
ENST00000509586 ENSP00000427284
ENST00000504391 ENSP00000422963
ENST00000512819 ENSP00000421618
ENST00000504790 ENSP00000427564
ENST00000515701 ENSP00000426099
ENST00000511901 ENSP00000423878
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001601 peptide YY receptor activity
GO:0001602 pancreatic polypeptide receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity
GO:0005515 protein binding
Biological Process
GO:0003151 outflow tract morphogenesis
GO:0006006 glucose metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007626 locomotory behavior
GO:0007631 feeding behavior
GO:0008217 regulation of blood pressure
GO:0019233 sensory perception of pain
GO:0040014 regulation of multicellular organism growth
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036437
View Gene Order
ENSBTAG00000047586
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P25929
TrEMBL B4DKL9 D6R9D0 D6RC44 D6REY0 D6RHH6 D6RI97
UniProt Splice Variant
Entrez Gene 4886
UniGene Hs.706693
RefSeq NM_000909 XM_005263031 XM_005263032
HUGO HGNC:7956
OMIM 162641
CCDS CCDS34089
HPRD
IMGT
EMBL AC079238 AK296624 AK312578 AY548168 BC036657 BC071720 CH471056 L07614 L07615 M84755 M88461
GenPept AAA59920 AAA59947 AAA73215 AAH36657 AAH71720 AAS55647 BAG35472 BAG59231 EAX04841
RNA Seq Atlas 4886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca