InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC30A6

Summary

InnateDB Protein

IDBP-43346.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC30A6

Protein Name

solute carrier family 30 (zinc transporter), member 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368648

InnateDB Gene

IDBG-43344 (SLC30A6)

Protein Structure

UniProt Annotation

Function

Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. {ECO:0000250}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis. {ECO:0000269PubMed:15154973, ECO:0000269PubMed:16580781}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005385	zinc ion transmembrane transporter activity
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006829	zinc ion transport
GO:0006895	Golgi to endosome transport
GO:0044267	cellular protein metabolic process
GO:0055085	transmembrane transport
GO:0071577	zinc ion transmembrane transport