Homo sapiens Protein: SLC30A6
Summary
InnateDB Protein IDBP-43348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC30A6
Protein Name solute carrier family 30 (zinc transporter), member 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000282587
InnateDB Gene IDBG-43344 (SLC30A6)
Protein Structure
UniProt Annotation
Function Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis. {ECO:0000269PubMed:15154973, ECO:0000269PubMed:16580781}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008324 cation transmembrane transporter activity
Biological Process
GO:0006812 cation transport
GO:0044267 cellular protein metabolic process
GO:0055085 transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002524 Cation efflux protein
PFAM PF01545
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NXT4
PhosphoSite PhosphoSite-Q6NXT4
TrEMBL B5MCR8
UniProt Splice Variant
Entrez Gene 55676
UniGene Hs.643379
RefSeq NP_060434
HUGO HGNC:19305
OMIM 611148
CCDS CCDS1780
HPRD 15368
IMGT
EMBL AK055663 AK096672 AK127716 AK304225 AL121653 AL121658 BC032525 BC066903 CH471053 EF560719 EF560726
GenPept AAH32525 AAH66903 ABQ59029 ABQ59036 BAB70980 BAG53349 BAG54557 BAH14137 EAX00456 EAX00457 EAX00458 EAX00460