InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BCMO1

Summary

InnateDB Protein

IDBP-43619.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCMO1

Protein Name

beta-carotene 15,15'-monooxygenase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000258168

InnateDB Gene

IDBG-43617 (BCMO1)

Protein Structure

UniProt Annotation

Function

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.

Subcellular Localization

Disease Associations

Hypercarotenemia and vitamin A deficiency, autosomal dominant (ADHVAD) [MIM:115300]: A disorder characterized by increased serum beta-carotene, decreased conversion of beta- carotene to vitamin A and decreased serum vitamin A. {ECO:0000269PubMed:17951468}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon. {ECO:0000269PubMed:11401432}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003834	beta-carotene 15,15'-monooxygenase activity
GO:0004497	monooxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0007603	phototransduction, visible light
GO:0035238	vitamin A biosynthetic process
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0055114	oxidation-reduction process