Version 5.4
Homo sapiens Gene: BCMO1
Summary
InnateDB Gene IDBG-43617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCMO1
Gene Name beta-carotene 15,15'-monooxygenase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000135697
Encoded Proteins
IDBP-43619
beta-carotene 15,15'-monooxygenase 1
IDBP-748752
IDBP-752286
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:81238448-81291142
Strand Forward strand
Band q23.2
Transcripts
ENST00000258168 ENSP00000258168
ENST00000564552 ENSP00000455219
ENST00000563804 ENSP00000457910
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003834 beta-carotene 15,15'-monooxygenase activity
GO:0004497 monooxygenase activity
GO:0046872 metal ion binding
Biological Process
GO:0001523 retinoid metabolic process
GO:0007603 phototransduction, visible light
GO:0035238 vitamin A biosynthetic process
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031845
View Gene Order
ENSBTAG00000001026
Not yet available
Pathways
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q9HAY6
TrEMBL H3BPA2 H3BV18
UniProt Splice Variant
Entrez Gene 53630
UniGene Hs.212172
RefSeq NM_017429
HUGO HGNC:13815
OMIM 605748
CCDS CCDS10934
HPRD
IMGT
EMBL AC009148 AC131888 AF294900 AK001592 BC126210 BC126212 CH471114
GenPept AAG15380 AAI26211 AAI26213 BAA91776 EAW95537
RNA Seq Atlas 53630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca