Version 5.4
Homo sapiens Protein: MARCH9
Summary
InnateDB Protein IDBP-43733.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH9
Protein Name membrane-associated ring finger (C3HC4) 9
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266643
InnateDB Gene IDBG-43731 (MARCH9)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. {ECO:0000269PubMed:14722266, ECO:0000269PubMed:17174307}.
Subcellular Localization Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:14722266}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005795 Golgi stack
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF12906
PF00097
PRINTS
PIRSF
SMART SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86YJ5
PhosphoSite PhosphoSite-Q86YJ5
TrEMBL Q8N9T1
UniProt Splice Variant
Entrez Gene 92979
UniGene Hs.632709
RefSeq NP_612405
HUGO HGNC:25139
OMIM 613336
CCDS CCDS31847
HPRD 14360
IMGT
EMBL AK093897 AK313925 BC009489 BC036455 BC050397 CH471054
GenPept AAH09489 AAH36455 AAH50397 BAC04247 BAG36646 EAW97065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca