InnateDB Protein
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IDBP-43923.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HAMP
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Protein Name
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hepcidin antimicrobial peptide
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000222304
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InnateDB Gene
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IDBG-43921 (HAMP)
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Protein Structure
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Function |
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). {ECO:0000269PubMed:22306005}.Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317). {ECO:0000269PubMed:11034317, ECO:0000269PubMed:11113131}.
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Subcellular Localization |
Secreted.
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Disease Associations |
Hemochromatosis 2B (HFE2B) [MIM:613313]: A juvenile form of hemochromatosis, a disorder of iron metabolism with excess deposition of iron in a variety of organs leading to their failure, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of juvenile hemochromatosis at presentation are hypogonadism and cardiomyopathy. {ECO:0000269PubMed:12915468, ECO:0000269PubMed:14630809, ECO:0000269PubMed:14633868, ECO:0000269PubMed:14670915, ECO:0000269PubMed:15099344}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine. {ECO:0000269PubMed:11034317}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR010500
Hepcidin
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PFAM |
PF06446
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P81172
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B6EU04
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UniProt Splice Variant |
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Entrez Gene |
57817
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UniGene |
Hs.8821
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RefSeq |
NP_066998
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HUGO |
HGNC:15598
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OMIM |
606464
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CCDS |
CCDS12454
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HPRD |
05925
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IMGT |
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EMBL |
AD000684
AF131292
AF309489
AJ277280
AY358669
BC020612
DQ496109
FM242480
FM242481
FM242482
FM242483
FM242484
FM242485
FM242486
FM242487
FM242488
FM242489
FM242490
FM242491
FM242492
FM242493
FM242494
FM242495
FM242496
FM242497
FM242498
FM242499
FM242500
FM242501
FM242502
FM242503
FM242504
FM242505
FM242506
FM242507
FM242508
FM242509
FM242510
FM242511
FM242512
FM242513
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GenPept |
AAG23966
AAH20612
AAK14912
AAQ89032
ABF47098
CAC09419
CAR82669
CAR82670
CAR82671
CAR82672
CAR82673
CAR82674
CAR82675
CAR82676
CAR82677
CAR82678
CAR82679
CAR82680
CAR82681
CAR82682
CAR82683
CAR82684
CAR82685
CAR82686
CAR82687
CAR82688
CAR82689
CAR82690
CAR82691
CAR82692
CAR82693
CAR82694
CAR82695
CAR82696
CAR82697
CAR82698
CAR82699
CAR82700
CAR82701
CAR82702
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