InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HAMP

Summary

InnateDB Gene

IDBG-43921.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAMP

Gene Name

hepcidin antimicrobial peptide

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105697

Encoded Proteins

IDBP-43923

hepcidin antimicrobial peptide

IDBP-763473

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21572427

HAMP (hepcidin), an iron regulatory hormone and antimicrobial peptide, inhibits the liver-stage infection in malarial parasitemia by arresting Plasmodium sporozoites in liver hepatocytes and prevents their development into blood-stage parasites. (Demonstrated in murine model)

PMID 21685415

HAMP expression in LPS or TNFA-stimulated peripheral blood leukocytes is dependent on the NFkB signalling pathway.

PMID 22544439

HAMP expression is induced by TLR2/TLR4 ligands and may regulate pro-inflammatory cytokine production through maintenance of iron homeostasis in macrophages. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 20530874

[Mus musculus] Hamp is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide, functioning in modulating acute inflammatory responses by mediating transcriptional changes.

PMID 21572427

[Mus musculus] Hamp (hepcidin), an iron regulatory hormone, inhibits the liver-stage infection in malarial parasitemia by arresting Plasmodium sporozoites in liver hepatocytes and prevents their development into blood-stage parasites.

PMID 21685415

[Mus musculus] Hamp expression in LPS or Tnfa-stimulated peripheral blood leukocytes is dependent on the NFkB signalling pathway. (Demonstrated in human)

PMID 22544439

[Mus musculus] Hamp expression is induced by Tlr2/Tlr4 ligands and may regulate pro-inflammatory cytokine production through maintenance of iron homeostasis in macrophages.

Entrez Gene

Summary

The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:35280716-35285143

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000222304	ENSP00000222304
ENST00000598398	ENSP00000471894
ENST00000593580

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0006955	immune response
GO:0031640	killing of cells of other organism
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0050832	defense response to fungus

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0045179	apical cortex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000050440

View Gene Order

ENSBTAG00000017042

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.8821

RefSeq

NM_021175

HUGO

OMIM

CCDS

CCDS12454

HPRD

05925

IMGT

EMBL

GenPept

RNA Seq Atlas