InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBA3

Summary

InnateDB Protein

IDBP-43926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA3

Protein Name

ubiquitin-like modifier activating enzyme 3

Synonyms

hUBA3; NAE2; UBE1C;

Species

Homo sapiens

Ensembl Protein

ENSP00000354340

InnateDB Gene

IDBG-43924 (UBA3)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression. {ECO:0000269PubMed:10207026, ECO:0000269PubMed:12740388, ECO:0000269PubMed:9694792}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10207026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016881	acid-amino acid ligase activity
GO:0019781	NEDD8 activating enzyme activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0007113	endomitotic cell cycle
GO:0045116	protein neddylation
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000127 Ubiquitin-activating enzyme repeat
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
IPR014929 E2 binding
IPR019572 Ubiquitin-activating enzyme

PFAM

PF02134
PF00899
PF08825
PF10585

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8TBC4

PhosphoSite