InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PALLD

Summary

InnateDB Protein

IDBP-43952.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PALLD

Protein Name

palladin, cytoskeletal associated protein

Synonyms

CGI151; MYN; PNCA1; SIH002;

Species

Homo sapiens

Ensembl Protein

ENSP00000261509

InnateDB Gene

IDBG-43950 (PALLD)

Protein Structure

UniProt Annotation

Function

Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. {ECO:0000269PubMed:11598191, ECO:0000269PubMed:15147863, ECO:0000269PubMed:17537434}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere, Z line. Note=Localizes to stress fibers and Z lines.

Disease Associations

Pancreatic cancer 1 (PNCA1) [MIM:606856]: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. {ECO:0000269PubMed:17194196, ECO:0000269PubMed:17415588}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=Genetic variations in PALLD may be associated with myocardial infarction.

Tissue Specificity

Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines. {ECO:0000269PubMed:11598191}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0051371	muscle alpha-actinin binding

Biological Process

GO:0007010

cytoskeleton organization

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005884	actin filament
GO:0005925	focal adhesion
GO:0030018	Z disc
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WX93