InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLYCD

Summary

InnateDB Protein

IDBP-43962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLYCD

Protein Name

malonyl-CoA decarboxylase

Synonyms

MCD;

Species

Homo sapiens

Ensembl Protein

ENSP00000262430

InnateDB Gene

IDBG-43960 (MLYCD)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. {ECO:0000269PubMed:10455107, ECO:0000269PubMed:15003260, ECO:0000269PubMed:18314420, ECO:0000269PubMed:23482565}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10417274}. Mitochondrion matrix {ECO:0000269PubMed:10417274}. Peroxisome {ECO:0000269PubMed:10417274}. Peroxisome matrix {ECO:0000250}. Note=Enzymatically active in all three subcellular compartments. {ECO:0000250}.

Disease Associations

Malonyl-CoA decarboxylase deficiency (MLYCD deficiency) [MIM:248360]: Autosomal recessive disease characterized by abdominal pain, chronic constipation, episodic vomiting, metabolic acidosis and malonic aciduria. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in fibroblasts and hepatoblastoma cells (at protein level). Expressed strongly in heart, liver, skeletal muscle, kidney and pancreas. Expressed in myotubes. Expressed weakly in brain, placenta, spleen, thymus, testis, ovary and small intestine. {ECO:0000269PubMed:10455107, ECO:0000269PubMed:18314420}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0050080	malonyl-CoA decarboxylase activity

Biological Process

GO:0002931	response to ischemia
GO:0006085	acetyl-CoA biosynthetic process
GO:0006633	fatty acid biosynthetic process
GO:0010906	regulation of glucose metabolic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046321	positive regulation of fatty acid oxidation
GO:2001294	malonyl-CoA catabolic process