InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARL6IP5

Summary

InnateDB Protein

IDBP-43981.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARL6IP5

Protein Name

ADP-ribosylation-like factor 6 interacting protein 5

Synonyms

addicsin; DERP11; GTRAP3-18; hp22; jmx; JWA; PRAF3;

Species

Homo sapiens

Ensembl Protein

ENSP00000273258

InnateDB Gene

IDBG-43979 (ARL6IP5)

Protein Structure

UniProt Annotation

Function

Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010917	negative regulation of mitochondrial membrane potential
GO:0015813	L-glutamate transport
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0043065	positive regulation of apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051051	negative regulation of transport

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome