Version 5.4
Homo sapiens Gene: ARL6IP5
Summary
InnateDB Gene IDBG-43979.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL6IP5
Gene Name ADP-ribosylation-like factor 6 interacting protein 5
Synonyms addicsin; DERP11; GTRAP3-18; hp22; jmx; JWA; PRAF3
Species Homo sapiens
Ensembl Gene ENSG00000144746
Encoded Proteins
IDBP-43981
ADP-ribosylation-like factor 6 interacting protein 5
IDBP-475799
ADP-ribosylation-like factor 6 interacting protein 5
IDBP-479005
ADP-ribosylation-like factor 6 interacting protein 5
IDBP-480192
ADP-ribosylation-like factor 6 interacting protein 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:69084944-69106066
Strand Forward strand
Band p14.1
Transcripts
ENST00000273258 ENSP00000273258
ENST00000484921 ENSP00000419374
ENST00000478935 ENSP00000420138
ENST00000470936
ENST00000485444 ENSP00000419021
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010917 negative regulation of mitochondrial membrane potential
GO:0015813 L-glutamate transport
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0051051 negative regulation of transport
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035199
View Gene Order
ENSBTAG00000021506
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518060 Hs.741289
RefSeq NM_006407
HUGO
OMIM
CCDS CCDS2912
HPRD 09303
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca