InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DMRT2

Summary

InnateDB Protein

IDBP-44032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DMRT2

Protein Name

doublesex and mab-3 related transcription factor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371690

InnateDB Gene

IDBG-44030 (DMRT2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00070}.

Disease Associations

Tissue Specificity

Expressed in testis, kidney and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007530	sex determination
GO:0008150	biological_process
GO:0008584	male gonad development