InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPA4

Summary

InnateDB Protein

IDBP-44106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPA4

Protein Name

heat shock 70kDa protein 4

Synonyms

APG-2; HEL-S-5a; HS24/P52; hsp70; hsp70RY; HSPH2; RY;

Species

Homo sapiens

Ensembl Protein

ENSP00000302961

InnateDB Gene

IDBG-44104 (HSPA4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 340 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	340 [view]
Protein-Protein	340 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006986	response to unfolded protein
GO:0045040	protein import into mitochondrial outer membrane
GO:0051131	chaperone-mediated protein complex assembly

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34932