InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRIM1

Summary

InnateDB Protein

IDBP-44118.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRIM1

Protein Name

cysteine rich transmembrane BMP regulator 1 (chordin-like)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000280527

InnateDB Gene

IDBG-44114 (CRIM1)

Protein Structure

UniProt Annotation

Function

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. {ECO:0000269PubMed:12464430, ECO:0000269PubMed:12805376}.

Subcellular Localization

Processed cysteine-rich motor neuron 1 protein: Secreted.Cell membrane {ECO:0000269PubMed:12805376}; Single-pass type I membrane protein {ECO:0000269PubMed:12805376}.

Disease Associations

Tissue Specificity

Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). {ECO:0000269PubMed:10642437, ECO:0000269PubMed:12464430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005010	insulin-like growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0030165	PDZ domain binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007399	nervous system development
GO:0010951	negative regulation of endopeptidase activity
GO:0048009	insulin-like growth factor receptor signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR001007 von Willebrand factor, type C
IPR004094 Antistasin-like domain
IPR006552 VWC out
IPR011061 Hirudin/antistatin

PFAM

PF00219
PF00093
PF02822

PRINTS

PIRSF

SMART

SM00121
SM00214
SM00215

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NZV1