Version 5.4
Homo sapiens Gene: CRIM1
Summary
InnateDB Gene IDBG-44114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRIM1
Gene Name cysteine rich transmembrane BMP regulator 1 (chordin-like)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000150938
Encoded Proteins
IDBP-44118
cysteine rich transmembrane BMP regulator 1 (chordin-like)
IDBP-372276
cysteine rich transmembrane BMP regulator 1 (chordin-like)
IDBP-372277
cysteine rich transmembrane BMP regulator 1 (chordin-like)
IDBP-372280
cysteine rich transmembrane BMP regulator 1 (chordin-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:36355926-36551135
Strand Forward strand
Band p22.2
Transcripts
ENST00000280527 ENSP00000280527
ENST00000426856 ENSP00000407636
ENST00000428774 ENSP00000415706
ENST00000413985 ENSP00000403120
ENST00000473403
ENST00000477491
ENST00000497236
ENST00000481321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005520 insulin-like growth factor binding
GO:0030165 PDZ domain binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007399 nervous system development
GO:0010951 negative regulation of endopeptidase activity
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024074
View Gene Order
ENSBTAG00000009020
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.670362 Hs.699247
RefSeq NM_016441 XM_005264357
HUGO
OMIM
CCDS CCDS1783
HPRD 08392
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca