InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USP15

Summary

InnateDB Protein

IDBP-44313.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USP15

Protein Name

ubiquitin specific peptidase 15

Synonyms

UNPH-2; UNPH4;

Species

Homo sapiens

Ensembl Protein

ENSP00000309240

InnateDB Gene

IDBG-44309 (USP15)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.

Experimentally validated
Total	137 [view]
Protein-Protein	136 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005160	transforming growth factor beta receptor binding
GO:0042802	identical protein binding
GO:0046332	SMAD binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008152	metabolic process
GO:0016579	protein deubiquitination
GO:0030509	BMP signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035520	monoubiquitinated protein deubiquitination
GO:0060389	pathway-restricted SMAD protein phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
IPR029071 Ubiquitin-related domain

PFAM

PF06337

PRINTS

PIRSF

SMART

SM00695

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q9Y4E8

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB011101 AC048342 AC079035 AC117370 AF013990 AF106069 AF153604 AK023703 AK292337 BC020688 BC063454 BC125123

GenPept

AAD41086 AAD52099 AAG28973 AAH20688 AAH63454 AAI25124 BAA25455 BAB14648 BAF85026

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca