InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP5

Summary

InnateDB Protein

IDBP-4439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP5

Protein Name

Rho GTPase activating protein 5

Synonyms

GFI2; p190-B; p190BRhoGAP; RhoGAP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000371897

InnateDB Gene

IDBG-4437 (ARHGAP5)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.

Disease Associations

Tissue Specificity

Expressed in kidney, brain, liver and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0042169	SH2 domain binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0006184	GTP catabolic process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0008361	regulation of cell size
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0032321	positive regulation of Rho GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001806 Small GTPase superfamily
IPR002713 FF domain
IPR008936 Rho GTPase activation protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00620
PF00071
PF01846

PRINTS

PR00449

PIRSF

SMART

SM00324
SM00441

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt