InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE9A

Summary

InnateDB Protein

IDBP-4452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE9A

Protein Name

phosphodiesterase 9A

Synonyms

HSPDE9A2;

Species

Homo sapiens

Ensembl Protein

ENSP00000291539

InnateDB Gene

IDBG-4450 (PDE9A)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. {ECO:0000269PubMed:18757755}.

Subcellular Localization

Isoform PDE9A1: Cell projection, ruffle membrane. Cytoplasm, perinuclear region. Golgi apparatus. Endoplasmic reticulum.Isoform PDE9A2: Cell projection, ruffle membrane. Cytoplasm, perinuclear region.Isoform PDE9A3: Cytoplasm. Endoplasmic reticulum.Isoform PDE9A17: Cytoplasm. Endoplasmic reticulum.

Disease Associations

Tissue Specificity

Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate. {ECO:0000269PubMed:12565835}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019934	cGMP-mediated signaling

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0032587	ruffle membrane
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt