InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP4A

Summary

InnateDB Protein

IDBP-44543.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP4A

Protein Name

ATPase, H+/K+ exchanging, alpha polypeptide

Synonyms

ATP6A;

Species

Homo sapiens

Ensembl Protein

ENSP00000262623

InnateDB Gene

IDBG-44541 (ATP4A)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Found in gastric mucosa.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.

Experimentally validated
Total	76 [view]
Protein-Protein	76 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0005524	ATP binding
GO:0008900	hydrogen:potassium-exchanging ATPase activity
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006810	transport
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0010155	regulation of proton transport
GO:0015672	monovalent inorganic cation transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0034220	ion transmembrane transport
GO:0042493	response to drug
GO:0045851	pH reduction
GO:0055085	transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR015127 Gastric H+/K+-transporter P-type ATPase, N-terminal
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM