InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EGFL6

Summary

InnateDB Protein

IDBP-44664.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGFL6

Protein Name

EGF-like-domain, multiple 6

Synonyms

MAEG; W80;

Species

Homo sapiens

Ensembl Protein

ENSP00000369976

InnateDB Gene

IDBG-44660 (EGFL6)

Protein Structure

UniProt Annotation

Function

May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0007275	multicellular organismal development
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030154	cell differentiation
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001881 EGF-like calcium-binding domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00629
PF07645

PRINTS

PR00020

PIRSF

SMART

SM00181
SM00137
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt