Version 5.4
Homo sapiens Gene: EGFL6
Summary
InnateDB Gene IDBG-44660.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGFL6
Gene Name EGF-like-domain, multiple 6
Synonyms MAEG; W80
Species Homo sapiens
Ensembl Gene ENSG00000198759
Encoded Proteins
IDBP-44662
EGF-like-domain, multiple 6
IDBP-44664
EGF-like-domain, multiple 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:13569605-13633575
Strand Forward strand
Band p22.2
Transcripts
ENST00000361306 ENSP00000355126
ENST00000380602 ENSP00000369976
ENST00000473826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007275 multicellular organismal development
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000402
View Gene Order
ENSBTAG00000017927
Not yet available
Cross-References
SwissProt Q8IUX8
TrEMBL
UniProt Splice Variant
Entrez Gene 25975
UniGene Hs.12844
RefSeq NM_001167890 NM_015507
HUGO HGNC:3235
OMIM 300239
CCDS CCDS14155 CCDS55370
HPRD
IMGT
EMBL AF186084 AF193055 AJ245671 AK075214 AK315018 AL117610 AY358333 BC038587 CH471074
GenPept AAF27812 AAG22483 AAH38587 AAQ88699 BAC11477 BAG37508 CAB56014 CAB92132 EAW98822
RNA Seq Atlas 25975

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca