InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PROK2

Summary

InnateDB Protein

IDBP-44700.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROK2

Protein Name

prokineticin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295618

InnateDB Gene

IDBG-44696 (PROK2)

Protein Structure

UniProt Annotation

Function

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.

Subcellular Localization

Secreted.

Disease Associations

Hypogonadotropic hypogonadism 4 with or without anosmia (HH4) [MIM:610628]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic- pituitary axis. In some cases, it is associated with non- reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269PubMed:17054399, ECO:0000269PubMed:23643382}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in PROK2 as well as in other HH- associated genes including PROKR2 (PubMed:23643382). {ECO:0000269PubMed:23643382}.

Tissue Specificity

Expressed in the testis and, at low levels, in the small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0019233	sensory perception of pain
GO:0043066	negative regulation of apoptotic process
GO:0045987	positive regulation of smooth muscle contraction