InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PROK2

Summary

InnateDB Gene

IDBG-44696.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PROK2

Gene Name

prokineticin 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163421

Encoded Proteins

IDBP-44698

prokineticin 2

IDBP-44700

prokineticin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein expressed in the suprachiasmatic nucleus (SCN) circadian clock that may function as the output component of the circadian clock. The secreted form of the encoded protein may also serve as a chemoattractant for neuronal precursor cells in the olfactory bulb. Proteins from other vertebrates which are similar to this gene product were isolated based on homology to snake venom and secretions from frog skin, and have been shown to have diverse functions. Mutations in this gene are associated with Kallmann syndrome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:71771656-71785206

Strand

Reverse strand

Band

p13

Transcripts

ENST00000295619	ENSP00000295619
ENST00000353065	ENSP00000295618

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007283	spermatogenesis
GO:0007623	circadian rhythm
GO:0008283	cell proliferation
GO:0019233	sensory perception of pain
GO:0043066	negative regulation of apoptotic process
GO:0045987	positive regulation of smooth muscle contraction

Cellular Component

GO:0005576

extracellular region

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030069

View Gene Order

ENSBTAG00000019330

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9HC23

TrEMBL

UniProt Splice Variant

Entrez Gene

60675

UniGene

RefSeq

NM_001126128 NM_021935

HUGO

HGNC:18455

OMIM

607002

CCDS

CCDS2916 CCDS46868

HPRD

IMGT

EMBL

AF182069 AF333025 AY349131 BC069395 BC096695 BC098110 BC098162 CH471055

GenPept

AAG16893 AAH69395 AAH96695 AAH98110 AAH98162 AAK49919 AAR06657 EAW65506

RNA Seq Atlas

60675