Version 5.4
Homo sapiens Protein: SRGAP1
Summary
InnateDB Protein IDBP-44725.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRGAP1
Protein Name SLIT-ROBO Rho GTPase activating protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347198
InnateDB Gene IDBG-44723 (SRGAP1)
Protein Structure
UniProt Annotation
Function GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. {ECO:0000269PubMed:11672528}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in brain, lung, kidney, and testis. {ECO:0000269PubMed:11672528}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0016477 cell migration
GO:0032321 positive regulation of Rho GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000198 Rho GTPase-activating protein domain
IPR001060 FCH domain
IPR001452 SH3 domain
IPR004216 L-fucose/L-arabinose isomerase, C-terminal
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain
PFAM PF00620
PF00611
PF00018
PF14604
PF07653
PRINTS PR00452
PIRSF
SMART SM00324
SM00055
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z6B7
PhosphoSite PhosphoSite-Q7Z6B7
TrEMBL
UniProt Splice Variant
Entrez Gene 57522
UniGene Hs.613169
RefSeq NP_065813
HUGO HGNC:17382
OMIM 606523
CCDS CCDS8967
HPRD 09406
IMGT
EMBL AB037725 BC053903
GenPept AAH53903 BAA92542

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca