Version 5.4
Homo sapiens Gene: SRGAP1
Summary
InnateDB Gene IDBG-44723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRGAP1
Gene Name SLIT-ROBO Rho GTPase activating protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196935
Encoded Proteins
IDBP-44725
SLIT-ROBO Rho GTPase activating protein 1
IDBP-603277
SLIT-ROBO Rho GTPase activating protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:63844293-64162221
Strand Forward strand
Band q14.2
Transcripts
ENST00000355086 ENSP00000347198
ENST00000537556
ENST00000543397 ENSP00000437948
ENST00000542381
ENST00000537585
ENST00000542841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0016477 cell migration
GO:0032321 positive regulation of Rho GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020121
View Gene Order
ENSBTAG00000011892
Not yet available
Pathways
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_19342
Inactivation of Cdc42 and Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.210751 Hs.593803 Hs.613169
RefSeq NM_020762
HUGO
OMIM
CCDS CCDS8967
HPRD 09406
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca