InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HERC2

Summary

InnateDB Protein

IDBP-4487.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HERC2

Protein Name

hect domain and RLD 2

Synonyms

D15F37S1; jdf2; MRT38; p528; SHEP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000261609

InnateDB Gene

IDBG-4485 (HERC2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. {ECO:0000269PubMed:20023648, ECO:0000269PubMed:20304803, ECO:0000269PubMed:22508508}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.

Disease Associations

Mental retardation, autosomal recessive 38 (MRT38) [MIM:615516]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT38 is characterized by global developmental delay affecting motor, speech, adaptive, and social development. Patients manifest autistic features, aggression, self-injury, impulsivity, and distractibility. {ECO:0000269PubMed:23065719}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	58 [view]
Protein-Protein	57 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0020037	heme binding
GO:0031625	ubiquitin protein ligase binding
GO:0032183	SUMO binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006886	intracellular protein transport
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005814	centriole
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000408 Regulator of chromosome condensation, RCC1
IPR000433 Zinc finger, ZZ-type
IPR000569 HECT
IPR000859 CUB domain
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR004939 Anaphase-promoting complex, subunit 10/DOC domain
IPR006624 Beta-propeller repeat TECPR
IPR008979 Galactose-binding domain-like
IPR009060 UBA-like
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR010606 Mib-herc2
IPR021097 CPH domain

PFAM