InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HPGD

Summary

InnateDB Protein

IDBP-44950.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPGD

Protein Name

hydroxyprostaglandin dehydrogenase 15-(NAD)

Synonyms

15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000296521

InnateDB Gene

IDBG-44946 (HPGD)

Protein Structure

UniProt Annotation

Function

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. {ECO:0000269PubMed:10837478, ECO:0000269PubMed:15574495, ECO:0000269PubMed:16828555}.

Subcellular Localization

Cytoplasm.

Disease Associations

Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1) [MIM:259100]: A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. {ECO:0000269PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cranioosteoarthropathy (COA) [MIM:259100]: A form of osteoarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. {ECO:0000269PubMed:18500342}. Note=The disease is caused by mutations affecting the gene represented in this entry.Isolated congenital nail clubbing (ICNC) [MIM:119900]: A rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. {ECO:0000269PubMed:18805827}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in colon epithelium (at protein level). {ECO:0000269PubMed:15574495}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004957	prostaglandin E receptor activity
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0050662	coenzyme binding
GO:0051287	NAD binding
GO:0070403	NAD+ binding

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007565	female pregnancy
GO:0007567	parturition
GO:0008152	metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0019372	lipoxygenase pathway
GO:0030728	ovulation
GO:0044281	small molecule metabolic process
GO:0045786	negative regulation of cell cycle
GO:0055114	oxidation-reduction process
GO:0070493	thrombin receptor signaling pathway
GO:0097070	ductus arteriosus closure
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR013968 Polyketide synthase, KR

PFAM

PF01370
PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt