Version 5.4
Homo sapiens Gene: HPGD
Summary
InnateDB Gene IDBG-44946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HPGD
Gene Name hydroxyprostaglandin dehydrogenase 15-(NAD)
Synonyms 15-PGDH; PGDH; PGDH1; PHOAR1; SDR36C1
Species Homo sapiens
Ensembl Gene ENSG00000164120
Encoded Proteins
IDBP-44948
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-44950
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-379850
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-481057
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-473355
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-476745
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-479085
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-483569
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-483983
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-600432
hydroxyprostaglandin dehydrogenase 15-(NAD)
IDBP-601907
hydroxyprostaglandin dehydrogenase 15-(NAD)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:174490177-174523154
Strand Reverse strand
Band q34.1
Transcripts
ENST00000296522 ENSP00000296522
ENST00000296521 ENSP00000296521
ENST00000422112 ENSP00000398720
ENST00000510835 ENSP00000427699
ENST00000510901 ENSP00000422418
ENST00000511499
ENST00000508330 ENSP00000425741
ENST00000509512
ENST00000506910 ENSP00000423066
ENST00000514584 ENSP00000423110
ENST00000512410
ENST00000504433 ENSP00000420892
ENST00000541923 ENSP00000438017
ENST00000542498 ENSP00000443644
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004957 prostaglandin E receptor activity
GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0050662 coenzyme binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0006693 prostaglandin metabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0008152 metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0019372 lipoxygenase pathway
GO:0030728 ovulation
GO:0044281 small molecule metabolic process
GO:0045786 negative regulation of cell cycle
GO:0055114 oxidation-reduction process
GO:0070493 thrombin receptor signaling pathway
GO:0097070 ductus arteriosus closure
GO:2001300 lipoxin metabolic process
Cellular Component
GO:0005829 cytosol
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031613
View Gene Order
ENSBTAG00000025942
Not yet available
Pathways
NETPATH
REACTOME
REACT_150149
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_150320
Synthesis of Lipoxins (LX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596913 Hs.612373 Hs.719490
RefSeq NM_000860 NM_001145816 NM_001256301 NM_001256305 NM_001256306 NM_001256307
HUGO
OMIM
CCDS CCDS3821 CCDS54821 CCDS58933 CCDS58934 CCDS58935
HPRD 03406
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca