Version 5.4
Homo sapiens Protein: GINS2
Summary
InnateDB Protein IDBP-45119.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GINS2
Protein Name GINS complex subunit 2 (Psf2 homolog)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000253462
InnateDB Gene IDBG-45117 (GINS2)
Protein Structure
UniProt Annotation
Function The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA. {ECO:0000269PubMed:17417653}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID
InterPro IPR016906 GINS complex, subunit Psf2, subgroup
IPR021151 GINS complex
PFAM PF05916
PRINTS
PIRSF PIRSF028998
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y248
PhosphoSite PhosphoSite-Q9Y248
TrEMBL M0R043
UniProt Splice Variant
Entrez Gene 51659
UniGene Hs.602488
RefSeq NP_057179
HUGO HGNC:24575
OMIM 610609
CCDS CCDS10953
HPRD 15197
IMGT
EMBL AC123908 AF125098 AF151880 AF201939 AK001275 BC003186 BC010164 BC062444 CH471114 CR457186
GenPept AAD34117 AAD39915 AAF86875 AAH03186 AAH10164 AAH62444 BAA91595 CAG33467 EAW95443 EAW95444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca