Version 5.4
Homo sapiens Protein: SERPINB4
Summary
InnateDB Protein IDBP-4512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINB4
Protein Name serpin peptidase inhibitor, clade B (ovalbumin), member 4
Synonyms LEUPIN; PI11; SCCA-2; SCCA1; SCCA2;
Species Homo sapiens
Ensembl Protein ENSP00000343445
InnateDB Gene IDBG-4510 (SERPINB4)
Protein Structure
UniProt Annotation
Function May act as a protease inhibitor to modulate the host immune response against tumor cells.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10956412}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
Disease Associations
Tissue Specificity Squamous cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0019899 enzyme binding
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P48594
PhosphoSite PhosphoSite-P48594
TrEMBL
UniProt Splice Variant
Entrez Gene 6318
UniGene Hs.123035
RefSeq NP_002965
HUGO HGNC:10570
OMIM 600518
CCDS CCDS11986
HPRD 02746
IMGT
EMBL AB035089 AK292212 BC017401 U19557 U19570 U19571 U19572 U19574 U19575 U19576 X89015
GenPept AAA92602 AAA97553 AAH17401 BAB21525 BAF84901 CAA61420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca