InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GPM6B

Summary

InnateDB Protein

IDBP-45294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPM6B

Protein Name

glycoprotein M6B

Synonyms

M6B;

Species

Homo sapiens

Ensembl Protein

ENSP00000349420

InnateDB Gene

IDBG-45290 (GPM6B)

Protein Structure

UniProt Annotation

Function

May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. {ECO:0000269PubMed:21638316}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with SERT at the plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0001503	ossification
GO:0007399	nervous system development
GO:0015031	protein transport
GO:0030154	cell differentiation
GO:0030501	positive regulation of bone mineralization
GO:0032956	regulation of actin cytoskeleton organization
GO:0051612	negative regulation of serotonin uptake
GO:0051893	regulation of focal adhesion assembly
GO:0085029	extracellular matrix assembly
GO:2000009	negative regulation of protein localization to cell surface