Version 5.4
Homo sapiens Protein: MSRB3
Summary
InnateDB Protein IDBP-45327.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSRB3
Protein Name methionine sulfoxide reductase B3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000347324
InnateDB Gene IDBG-45323 (MSRB3)
Protein Structure
UniProt Annotation
Function Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. {ECO:0000269PubMed:14699060, ECO:0000269PubMed:21185009}.
Subcellular Localization Isoform 1: Endoplasmic reticulum.Isoform 2: Mitochondrion.
Disease Associations Deafness, autosomal recessive, 74 (DFNB74) [MIM:613718]: A form of non-syndromic sensorineural deafness characterized by prelingual, bilateral, profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269PubMed:21185009}. Note=The disease is caused by mutations affecting the gene represented in this entry. A nonsense mutation affecting exclusively mitochondrial isoform 2 is sufficient to produce hearing loss.
Tissue Specificity Widely expressed. {ECO:0000269PubMed:15914630, ECO:0000269PubMed:21185009}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0033743 peptide-methionine (R)-S-oxide reductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0030091 protein repair
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR002579 Peptide methionine sulphoxide reductase MrsB
IPR011057 Mss4-like
PFAM PF01641
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IXL7
PhosphoSite PhosphoSite-Q8IXL7
TrEMBL Q6MZU8
UniProt Splice Variant
Entrez Gene 253827
UniGene Hs.639220
RefSeq NP_932346
HUGO HGNC:27375
OMIM 613719
CCDS CCDS8973
HPRD 14785
IMGT
EMBL AK293084 AK299065 AK316365 AY358229 BC040053 BX640871 BX648776
GenPept AAH40053 AAQ88596 BAF85773 BAG61131 BAH14736 CAE45929 CAI46018

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca