Version 5.4
Homo sapiens Gene: MSRB3
Summary
InnateDB Gene IDBG-45323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSRB3
Gene Name methionine sulfoxide reductase B3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174099
Encoded Proteins
IDBP-45325
methionine sulfoxide reductase B3
IDBP-45327
methionine sulfoxide reductase B3
IDBP-366554
methionine sulfoxide reductase B3
IDBP-598435
methionine sulfoxide reductase B3
IDBP-583524
methionine sulfoxide reductase B3
IDBP-589653
methionine sulfoxide reductase B3
IDBP-590961
methionine sulfoxide reductase B3
IDBP-598471
methionine sulfoxide reductase B3
IDBP-603268
methionine sulfoxide reductase B3
IDBP-812920
methionine sulfoxide reductase B3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:65278643-65488244
Strand Forward strand
Band q14.3
Transcripts
ENST00000308259 ENSP00000312274
ENST00000355192 ENSP00000347324
ENST00000446731 ENSP00000404903
ENST00000541897 ENSP00000445051
ENST00000538725
ENST00000540804 ENSP00000437623
ENST00000535664 ENSP00000441650
ENST00000541189 ENSP00000440722
ENST00000538045 ENSP00000442620
ENST00000535239 ENSP00000445843
ENST00000535143
ENST00000614640 ENSP00000481483
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0033743 peptide-methionine (R)-S-oxide reductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0030091 protein repair
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051236
View Gene Order
ENSBTAG00000044017
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.339024 Hs.639220
RefSeq NM_001031679 NM_001193460 NM_001193461 NM_198080
HUGO
OMIM
CCDS CCDS31853 CCDS8973
HPRD 14785
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca