Version 5.4
Homo sapiens Protein: MYL12A
Summary
InnateDB Protein IDBP-454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYL12A
Protein Name myosin, light chain 12A, regulatory, non-sarcomeric
Synonyms HEL-S-24; MLCB; MRCL3; MRLC3; MYL2B;
Species Homo sapiens
Ensembl Protein ENSP00000217652
InnateDB Gene IDBG-452 (MYL12A)
Protein Structure
UniProt Annotation
Function Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
Experimentally validated
Total 51 [view]
Protein-Protein 51 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0035254 glutamate receptor binding
Biological Process
GO:0008360 regulation of cell shape
GO:0072661 protein targeting to plasma membrane
Cellular Component
GO:0001725 stress fiber
GO:0016460 myosin II complex
GO:0030018 Z disc
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19105
PhosphoSite PhosphoSite-P19105
TrEMBL Q2F834
UniProt Splice Variant
Entrez Gene 10627
UniGene Hs.734070
RefSeq NP_006462
HUGO HGNC:16701
OMIM 609211
CCDS CCDS11830
HPRD 14735
IMGT
EMBL AK291145 AP005329 BC016372 BC031972 BC032748 CH471113 D82059 DQ185044 EU794621 X54304
GenPept AAH16372 AAH31972 AAH32748 ABD14424 ACJ13675 BAB88919 BAF83834 CAA38201 EAX01678 EAX01680 EAX01681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca