Version 5.4
Homo sapiens Protein: KEL
Summary
InnateDB Protein IDBP-45410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KEL
Protein Name Kell blood group, metallo-endopeptidase
Synonyms CD238; ECE3;
Species Homo sapiens
Ensembl Protein ENSP00000347409
InnateDB Gene IDBG-45408 (KEL)
Protein Structure
UniProt Annotation
Function Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. {ECO:0000269PubMed:10438732}.
Subcellular Localization Cell membrane; Single-pass type II membrane protein. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
Disease Associations
Tissue Specificity Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow. {ECO:0000269PubMed:10891471, ECO:0000269PubMed:11336649}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0042310 vasoconstriction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR008753 Peptidase M13, N-terminal domain
IPR018497 Peptidase M13, C-terminal domain
PFAM PF05649
PF01431
PRINTS PR00786
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23276
PhosphoSite PhosphoSite-P23276
TrEMBL W5XPJ0
UniProt Splice Variant
Entrez Gene 3792
UniGene Hs.368588
RefSeq NP_000411
HUGO HGNC:6308
OMIM 613883
CCDS CCDS34766
HPRD 00194
IMGT
EMBL AC099652 AF172609 AF172610 AF172611 AF172612 AF172613 AF172614 AF172615 AF172616 AF172617 AF172618 AF172619 AF172620 AF172621 AF172622 AF172623 AF172624 AF172625 AF172626 AF172627 AF279657 AK314831 AM085113 AM085114 AM085115 AM085117 AM085118 AM085122 AM085124 AM085125 AM085126 AM085127 AM085128 AM902715 AY228336 BC003135 BC050639 CH471198 DQ905957 DQ923321 EF208899 KF993655 M64934 S80081
GenPept AAA03192 AAB33459 AAB47018 AAH03135 AAH50639 AAK69488 AAO38053 ABI75043 ABI96895 ABN11470 AHI18583 BAG37351 CAJ30267 CAJ30268 CAJ30269 CAJ30271 CAJ30272 CAJ30276 CAJ30278 CAJ30279 CAJ30280 CAJ30281 CAJ30282 CAP18775 EAW51891

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca