InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DOCK9

Summary

InnateDB Protein

IDBP-45552.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DOCK9

Protein Name

dedicator of cytokinesis 9

Synonyms

ZIZ1; ZIZIMIN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000365643

InnateDB Gene

IDBG-45550 (DOCK9)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269PubMed:12172552, ECO:0000269PubMed:19745154}.

Subcellular Localization

Endomembrane system {ECO:0000305}. Note=Associated with membranes. {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle. {ECO:0000269PubMed:12172552}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0017048	Rho GTPase binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0008150	biological_process
GO:0032319	regulation of Rho GTPase activity

Cellular Component

GO:0005575	cellular_component
GO:0005829	cytosol
GO:0012505	endomembrane system
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001849 Pleckstrin homology domain
IPR010703 Dedicator of cytokinesis C-terminal
IPR016024 Armadillo-type fold
IPR021816 Dedicator of cytokinesis C/D, N-terminal

PFAM

PF00169
PF06920
PF11878

PRINTS

PIRSF

SMART

SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BZ29