Version 5.4
Homo sapiens Protein: GLRA2
Summary
InnateDB Protein IDBP-45613.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLRA2
Protein Name glycine receptor, alpha 2
Synonyms GLR;
Species Homo sapiens
Ensembl Protein ENSP00000347123
InnateDB Gene IDBG-45609 (GLRA2)
Protein Structure
UniProt Annotation
Function The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
GO:0016594 glycine binding
GO:0016934 extracellular-glycine-gated chloride channel activity
GO:0022824 transmitter-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007218 neuropeptide signaling pathway
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008127 Glycine receptor alpha
IPR008129 Glycine receptor alpha2
PFAM PF02932
PF02931
PRINTS PR00253
PR00252
PR01673
PR01675
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23416
PhosphoSite PhosphoSite-P23416
TrEMBL
UniProt Splice Variant
Entrez Gene 2742
UniGene Hs.641859
RefSeq NP_001112358
HUGO HGNC:4327
OMIM 305990
CCDS CCDS48085
HPRD 02379
IMGT
EMBL AC003658 AC003683 AF053487 AF053488 AF053489 AF053490 AF053491 AF053492 AF053493 AF053494 AF053495 AK289561 AK297304 AK312591 AY437083 AY437084 BC032864 CH471074 CR450343 U77724 U77725 U77726 U77727 U77728 U77729 U77730 U77731 X52008
GenPept AAB38272 AAB38273 AAC35290 AAH32864 AAR87842 AAR87843 BAF82250 BAG35485 BAH12541 CAA36257 CAG29339 EAW98859 EAW98860

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca