InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SNX6

Summary

InnateDB Protein

IDBP-4566.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX6

Protein Name

sorting nexin 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355217

InnateDB Gene

IDBG-4564 (SNX6)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B (By similarity). Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation. {ECO:0000250, ECO:0000269PubMed:19935774, ECO:0000269PubMed:20354142, ECO:0000269PubMed:20830743}.

Subcellular Localization

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes. Only a minor proportion is seen in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006886	intracellular protein transport
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042147	retrograde transport, endosome to Golgi
GO:0045892	negative regulation of transcription, DNA-templated