InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NEUROG1

Summary

InnateDB Protein

IDBP-45660.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NEUROG1

Protein Name

neurogenin 1

Synonyms

AKA; bHLHa6; Math4C; NEUROD3; ngn1;

Species

Homo sapiens

Ensembl Protein

ENSP00000317580

InnateDB Gene

IDBG-45658 (NEUROG1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expression restricted to the embryonic nervous system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0022008	neurogenesis
GO:0030182	neuron differentiation
GO:0031536	positive regulation of exit from mitosis
GO:0042472	inner ear morphogenesis
GO:0045165	cell fate commitment
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity