Version 5.4
Homo sapiens Protein: HELB
Summary
InnateDB Protein IDBP-45663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HELB
Protein Name helicase (DNA) B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000247815
InnateDB Gene IDBG-45661 (HELB)
Protein Structure
UniProt Annotation
Function Unwinds duplex DNA with 5'-3' polarity. Has single- strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress. {ECO:0000269PubMed:12181327, ECO:0000269PubMed:22194613}.
Subcellular Localization Note=Preferentially during S phase, recruited to chromatin following DNA damage induced by UV irradiation, or camptothecin or hydroxyurea treatment.
Disease Associations
Tissue Specificity Highly expressed in testis and thymus and weakly in liver, spleen, kidney and brain. {ECO:0000269PubMed:12181327}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004003 ATP-dependent DNA helicase activity
GO:0005524 ATP binding
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006269 DNA replication, synthesis of RNA primer
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005658 alpha DNA polymerase:primase complex
Protein Structure and Domains
PDB ID
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NG08
PhosphoSite PhosphoSite-Q8NG08
TrEMBL
UniProt Splice Variant
Entrez Gene 92797
UniGene Hs.505941
RefSeq NP_387467
HUGO HGNC:17196
OMIM 614539
CCDS CCDS8976
HPRD 09979
IMGT
EMBL AF319995 AK024464 AK290894
GenPept AAM73554 BAB15754 BAF83583

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca