InnateDB Protein
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IDBP-45675.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CXCL14
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Protein Name
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chemokine (C-X-C motif) ligand 14
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Synonyms
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BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC; SCYB14;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000337065
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InnateDB Gene
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IDBG-45673 (CXCL14)
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Protein Structure
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Function |
Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. {ECO:0000269PubMed:10049774, ECO:0000269PubMed:10946286}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte- derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes. {ECO:0000269PubMed:10049774, ECO:0000269PubMed:10854217, ECO:0000269PubMed:10946286}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001811
Chemokine interleukin-8-like domain
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PFAM |
PF00048
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PRINTS |
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PIRSF |
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SMART |
SM00199
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TIGRFAMs |
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Modification |
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SwissProt |
O95715
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PhosphoSite |
PhosphoSite-O95715
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9547
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UniGene |
Hs.644699
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RefSeq |
NP_004878
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HUGO |
HGNC:10640
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OMIM |
604186
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CCDS |
CCDS4188
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HPRD |
16049
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IMGT |
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EMBL |
AC034206
AF073957
AF106911
AF144103
AK075514
AY358906
BC003513
BT007080
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GenPept |
AAD03839
AAD38944
AAF78449
AAH03513
AAP35743
AAQ89265
BAG52160
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